More on Original Antigenic Sin and the Folly of Our Universal Vaccination Campaign | WHAT REALLY HAPPENED X-Frame-Options: SAMEORIGIN

More on Original Antigenic Sin and the Folly of Our Universal Vaccination Campaign

To review: We have now had ten months of mass vaccination against SARS-CoV-2. Nearly 7 billion doses have been administered worldwide. This unprecedented campaign has not eradicated Corona; it has not even suppressed infections. Instead, case statistics have ballooned almost everywhere. While the vaccinated appear to enjoy some protection against severe outcomes, skyrocketing transmission means most countries have seen little benefit, on balance, from their universal vaccination campaigns. The most pressing question has become, simply: What is going on?

I’ve explored a few different possibilities. First, there seems to be a Marek Effect at work. We might imagine that all viruses have an optimal level of population-wide virulence – an advantageous degree of aggression at which they can spread effectively, while not driving their hosts underground too soon. Certain Delta sub-strains, previously punished for their excessive aggression in unvaccinated populations, have likely been favoured by the vaccines, which reduce symptoms in the vaccinated without preventing infection for more than a few months. Our vaccines reduced the average virulence of SARS-2, and the virus adapted to reattain the prior, optimal balance.

But the virus and its interactions with human hosts constitute a complex system. In such systems, it is very unlikely that any effect can be put down to a single cause. The Public Health England data provide powerful reasons to suspect that the vaccines may be compromising immunity to SARS-2 via Original Antigenic Sin. This is not a crazy internet fantasy, but a well-observed limitation of human immunity. It is the primary reason that respiratory viruses like influenza return again and again. Despite multiple reinfections across the whole population, we are never quite immune to the flu, because its strategy is to exploit the way our immune systems learn.

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