Protein impurities found in AstraZeneca’s Covid-19 vaccine stir debate | WHAT REALLY HAPPENED

Protein impurities found in AstraZeneca’s Covid-19 vaccine stir debate

Researchers in Germany report substantial amounts of human and viral proteins in AstraZeneca’s coronavirus vaccine. Although the study is not yet peer reviewed, it suggests that these impurities could be linked to the strong reaction seen in many people two to three days after their jab. The preprint also states that it is conceivable, albeit doubtful, that these proteins could be linked to rare blood-clotting events.

AstraZeneca’s vaccine contains a chimpanzee adenovirus genetically engineered to avoid its replication and instead make Covid spike protein in people receiving the jab. The human protein impurities – mostly heat shock and cell scaffold proteins – come from the human kidney cell line used to generate the chimp adenovirus. Viral proteins important for the virus during replication in producer cells were also present.

The study’s lead researcher, Stefan Kochanek from Ulm University, says he was surprised by the quantities of proteins detected by mass spectrometry in three vaccine lots. ‘At least half of the proteins present in the vaccine are of human origin,’ Kochanek says. One vaccine lot contained about 12.5?g of virus in one dose and about 22?g of non-virus proteins.

The adenovirus vector is obtained by disrupting cultured mammalian cells infected with the virus, and the viruses are then purified. ‘If that procedure is not super perfect, then you end up with what we see here: the presence of proteins from the production cells, which is why we call them process-related impurities,’ Kochanek explains.

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